Cell and Tissue Based Molecular Pathology by Jianping Qiu
English | 2024 | ISBN: 1682519015 | 308 pages | PDF | 27 Mb
Molecular pathology is an integral and essential component of diagnostic pathology, especially in the diagnosis of infectious diseases. Molecular pathology has come a long way from basic histopathological examination of tissues to aid diagnosis. Diagnostic molecular pathology, the discipline that determines the molecular aberrations present in tumors for diagnostic, prognostic or predictive purposes, is faced with true challenges. The laboratories have to meet the need of comprehensive molecular testing using only limited amount of tumor tissue, mostly fixed in formalin and embedded in paraffin (FFPE), in short turnaround time. Choices must be made for analytical methods that provide accurate, reliable and cost effective results. Validation of the test procedures and results is essential. In addition, participation and good performance in internal (IQA) and external quality assurance (EQA) schemes is mandatory.
Due to the fast increase of available targeted therapies as well, the TCGA efforts rapidly result in a growing demand for routine molecular tumor diagnostics and screening for actionable mutations in a wide variety of tumor types. To offer patients the best treatment options for a certain tumor, diagnostic tests should be reliable, reproducible, of sufficient high sensitivity, and able to investigate all potential targets with the constrains of limited amount of tissue, time and budget. These criteria for comprehensive molecular testing require permanent development of new assays, awareness of their potentials and drawbacks, continuous quality assessment to improve testing of diagnostic tissues, consciousness of budget and costs and clinical demands such as turnaround time. Apart from these issues there are tissue^ and technological challenges as well.
The book presents topics on molecular mechanisms, diagnostics, and therapeutics of human disease and relevant experimental models using cellular, molecular, biological, chemical and immunological approaches. This book covers the anatomy, embryology, histology, function, and growth regulation of various differentiated tissues including Pathology, Cell Biology and Physiology, Medicine, and Surgery who have ongoing research in these areas. The book is designed to offer detailed information on specific tissues, tissue-tissue interactions, and overlapping cellular and molecular pathways that exist in multiple tissues.
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